From Vials to Pre-Filled Syringes: The Evolution of HA Fillers

Last Updated: August 4, 2025 by Michael Kahn. Published: August 4, 2025.

In the early days of hyaluronic acid fillers, these anti-aging products were typically supplied in vials. Practitioners would need to manually draw the product into syringes before administering injections, which could be a bit of a hassle, especially with thicker, more dense fillers. The process of drawing these high-density fillers could be slow and required more effort, and it often left a small amount of product clinging to the vial walls, leading to some minor waste.

Over time, as the industry recognized the need for more convenient, faster, and safer solutions, the shift to pre-filled syringes became more widespread.

Today, the majority of popular hyaluronic acid fillers come in these ready-to-use syringes, streamlining the procedure and ensuring a higher standard of safety and efficiency. This not only saves time but also reduces cumulative product waste for clinicians over the long term, improving results in wrinkle correction and facial volume restoration.

Skin Boosters and Mesotherapy: Pre-Mixed for Convenience

In the early days of mesotherapy and skin boosters, these treatments were often supplied in vials, requiring practitioners to mix ingredients and draw the solution into syringes manually.

While the solutions were less viscous and didn’t leave much waste, the process still involved extra steps and potential for contamination. Similar to the evolution of hyaluronic acid fillers, the industry has now moved towards pre-mixed, ready-to-use formats, particularly popular in Korean aesthetic practice.

This transition has made the process more efficient and reduced contamination risks, contributing to more consistent anti-aging effects in clinical settings.

Pre-Diluted Botulinum Toxin: Slowly Gaining Ground

When it comes to botulinum toxin, the introduction of pre-diluted forms like Innotox 50u in 2011 marked a shift towards convenience and ease of use. However, despite the benefits, this trend has been slow to overtake the traditional powdered forms.

One key reason is that the powdered toxins allow clinicians to customize the concentration to suit each patient’s needs, offering greater flexibility. 

While pre-diluted products simplify the process and reduce preparation time, they also limit the ability to create a stronger solution if needed. As a result, many practitioners still prefer the traditional method, even though the convenience of pre-diluted options continues to gain interest. 

For those looking to explore these options, online shops like To The Beauty offer a variety of both traditional and pre-diluted botulinum toxins, like Innotox 50 units or unidades, making it easier for practitioners to choose what works best for them.

Over time, we might see a gradual increase in the adoption of pre-diluted forms, especially in South Korea, but for now, it’s a slowly evolving trend in muscle-relaxing injection procedures.